CategoriesNarcolepsy

The History of Narcolepsy – Discovery and Science

Narcolepsy has been plaguing the human existence for centuries, with no known explanation as to why the brain shuts down, and the body goes into a form of sleep paralysis. Narcoleptic history is a touch and go subject because in the ancient times documents were not kept as accurately as they are today, and the documents that were kept were either destroyed, or cannot be deciphered.  The history of narcolepsy in human beings is taken down by a physician and kept in an extensive medical file for that patient.

With each new case of narcolepsy the history and everything that is known about the brain and how it works is added to and carefully studied. Scientists have done extensive research to understand what is triggered when a cataplectic attack happens. With every sleep study that is preformed brain wave activity is measure, how long an episode lasts, and what happened before the attack happened is also carefully recorded to make sure that everything is properly noted.

Narcolepsy and Animals

Narcolepsy not only is a human disorder, but it also affects dogs and horses. This disorder works the same way in animals as it does in human beings:

  • Fatigue
  • Depression
  • Moodiness
  • Lost time
  • Sleep paralysis

All of these happen when a person has a history of narcolepsy, and most of time it has been diagnosed by a physician or a vet. The history of narcolepsy in horses is a little less definitive, because narcolepsy in horses is rare and often mistaken for a sleep apnea. Muscle fatigue and weight loss are both signs of a sleeping disorder, but not always narcolepsy when it comes to a horse. The signs are more noticeable, like standing still in mid step, are a general bad mood. While looking for these symptoms, the owner or trainer of the horse should also consult a veterinarian.

The canine history of narcolepsy is caused by a disruption of hypocretin receptor 2 genes or Hcrtr2, what the Hcrtr2 gene does is activates the brains sleeping agent making the body want to sleep and rest when the brain does not need to do so. With significant research being done with canines scientists have determined that the trait first developed in Labrador retrievers and Dobermans, and the gene was bred into them much like that of a horse retaining that trait from their parentage.

With each study that was taken with the dogs a pattern began to emerge with the breeds that had been back breed or had the same parents and brothers and sisters, the pattern clearly pointed out that the canines that were back breed had a greater likely hood of contracting the narcoleptic gene trait and making the animal more susceptible to having narcolepsy.  The traits and genes are passed down from parent to child and continue down through the line. As the line continues throughout the years the narcoleptic trait becomes stronger and the chances of having the gene activate is greatly increased.

Narcolepsy-Cataplexy

When sleepiness and cataplexy become a factor in life and daytime sleep is needed to function normally, it becomes harder to deal with normal society, and daily functions. When falling asleep or waking after an episode has hit, the lack of muscle functions is hard to get over. The body does not want to move or respond no matter how hard the person tries to move or respond to a simple command because of the sudden attack leaves the muscles in a weakened state.

The lack of muscle usage is one of the main problems for people with narcolepsy, some episodes can take place while driving and the lack of motor control is a main cause of motor accidents for people with narcolepsy.

Nighttime sleep is hard to get when a person has narcolepsy with cataplexy, because of the need to sleep during the day. The body will get the initial six to eight hours of sleep required to function but not at the normal time. When the body has a cataplectic attack it will shut down and sometimes even do automatic responses such as eating, speaking, driving, reading, writing, cooking, and cleaning. Some of the auto responses are not as dangerous as the others but, cooking; eating and driving can all have fatal ends. Eating sounds like it would not have a fatal end when having a cataplectic attack but the person could choke, on their food and not being able to respond correctly could kill them.

Narcolepsy and its history has changed over the years and course of study, with therapy, and regular medical examinations narcolepsy and all of the effects can be controlled with medication, life style changes and sleep studies, a patients narcolepsy can be controlled and even prevented.

With regular treatment the signs of narcolepsy such as hallucinations, daytime sleepiness, fatigue, depression, and lack of interest in things can be changed. With the advances that have been made in the neurological field the studies that have been made on the brain and mapping each quadrant, greatly increases the understanding of not only how the brain works but as to why the brain sometimes has a deficiency. Another study shows that the narcoleptic trait has origins of being an auto immune disease or closely related to it.

With the studies that are being made and advances in science the narcolepsy history is being easier defined and laid out for people to understand. The fact that right before people fall asleep or hypnogogic is a crucial time for people with narcolepsy, because of how the muscle tone either tenses up or completely relaxes all depends how sever a cataplectic attack is going to be.

Throughout history narcolepsy has been a factor in lives and now in our modern world there is a potential cure for narcolepsy. The treatments that have been developed, and the ones that are still being developed for this disorder have come a long way and have been a really big help for making the lives of people with narcolepsy easier to cope with.

CategoriesADHD,  Narcolepsy

Narcolepsy in Horses is Genetic

Narcolepsy in Horses is Genetic

The idea that horses can have narcolepsy is kind of an inconceivable concept, because narcolepsy is mainly associated with human beings and not with animals. The effect of narcolepsy in horses is much the same as it is in human beings the sleepiness, disorientation, hallucinations, and mood changes, are all evident in horses with narcolepsy.

Horses and Narcolepsy

In horses the most observable trait is that of narcolepsy with cataplexy, the other traits are harder to recognize. The symptoms of narcolepsy are hard to diagnose in a human patient that can tell the physician exactly what is going on and give and extensive medical history, but for animals that is even harder. This disorder is still being examined and studied, but as time goes by the cause still seems to elude physicians as to why narcolepsy has such an effect on the brain. With every new occurrence of narcolepsy showing up in animals physicians are more prone to believe that the brain is similar in more ways than originally thought.

Signs to Look For in Horses for Narcolepsy

  • depression
  • lack of interest in food
  • fatigue
  • moodiness
  • weak muscles

With these signs and symptoms being noticed in horses, even from a young age, this can make a breeder believe that the horse is from bad stock and sometime the owner puts the animal down because of such negative qualities.  Without there being a proper way to diagnose an animal let alone a horse with narcolepsy, many mistakes are made and eventually the animal suffers massively from this disorder. Veterinarians are working on ways to properly diagnose animals that have the narcoleptic symptoms, almost in the same fashion that physicians are working so earnestly to find a way to properly diagnose and treat this disorder.

Some veterinarians are trying experimental medications high-performance liquid chromatography or HPLC has been used in experiments to determine  if the drug will have a negative or positive effect on the horses and if so what dosage and how often should HPLC be used on the horses. Depending on the severity of the narcoleptic symptoms and the weight of the horse that the injection is being given to the HPLC drug can be very effective.

Narcolepsy and horses make a very interesting study the main thing to look for when it comes to the horse species and narcolepsy is constant fatigue, daytime sleepiness, and the unwillingness to do any form of physical activity. With these initial traits being noticed a trainer or owner has a better chance at identifying what is happening to the horse, if not then the horse can cause muscle problems, malnutrition, and could even cause broken bones from falling, or if hallucinating harm other animals and people around them because the animal could be easily spooked. With narcoleptic horses, it can become harder to train them and work with them because of the general lack of interest, and constant fatigue. Horses suffering from narcolepsy have a harder time going about their daily routines and life, without there being a risk to those around them as well as to their selves because of the lack of muscle control when falling asleep or waking up.

Bloodlines

Narcolepsy in horses is rare and often is bred into the horse by the parents that already have the existing narcoleptic gene in their system. Most horses have a form of sleep deprivation caused from over exercise, low food intake, and even missing fellow companions. This sleep disorder is a form of ED or extreme drowsiness, and can be observed when a horse seems to partially collapse and instead of going all the way to the ground and staying there to recuperate from the episode the horse will immediately regain their footing, and the cycle of partially collapsing and regaining their footing will begin all over again. With this occurring muscles can be pulled and harm can also be done to the ligaments in the fore legs and hind quarters.

These injuries can lead to even worse problems in the long run; they can even make a horse come up lame and no longer able to be ridden. Narcolepsy on horses can be just as hard if not even worse due to the fact that when horses sleep they sleep while standing; if they were to lie down for an extended period of time the weight and pressure being exuded could crush internal organs and break bones.

Horses suffering from narcolepsy, like human beings have lapses in time where they fall asleep and their bodies tense up causing a form of sleep paralysis, so if a horse has a cataplectic attack and suffers from a sleep paralysis, and falls then the damage can be irreparable and sometimes even fatal.

The narcolepsy in horses can even cause harm to the owner or person that is riding the horse because if a sudden attack should happen while riding say down a steep mountain side, the rider would be thrown from the saddle and become injured.  So before riding a horse that has all of the symptoms of narcolepsy have it checked out by a veterinarian, to make sure that the horse is properly diagnosed and all safety measurements are taken before training or riding the horse.

While inspecting the horse make sure that it is receiving enough nighttime sleep and is not disturbed, especially if that particular horse is a mare that is about to foal, or give birth. Rest is needed for such a difficult and delicate situation as giving birth for a mare as well as the young colt that is being born. The narcoleptic trait will not be immediately noticeable in new born colts because they require a lot of rest, so even if a young colt is sleeping during the day that does not mean that they have narcolepsy.

The earliest age to begin looking for the narcolepsy trait in a horse is around a year and a half, by then the horse should be healthy enough to withstand going through the day without needing to stop and take a rest. If the symptoms of narcolepsy are there go to your local veterinarian and ask what narcolepsy in horses is? With the help of a vet then the animal will receive the attention and help that is needed to make sure that the animal remains healthy.

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